Tossicità specifica per organi bersaglio – esposizione ripetuta (CLP): categorie, pittogramma e sostanze classificate

La classe di pericolo Tossicità specifica per organi bersaglio – esposizione ripetuta (codice STOT RE, pericolo di tipo salute) è una delle classi previste dal Regolamento CLP (CE) n. 1272/2008. In questa pagina trovi cosa significa, le categorie, il pittogramma e l'avvertenza associati e un elenco di sostanze con questa classificazione armonizzata, ciascuna collegata alla propria scheda.

Che cos'è la classe STOT RE

«Tossicità specifica per organi bersaglio – esposizione ripetuta» è la denominazione della classe di pericolo: indica il tipo di pericolo che la sostanza presenta. La gravità è espressa dalla categoria (ad esempio 1, 1A, 1B, 2, 3): più basso è il numero, maggiore è il pericolo. A ogni categoria corrispondono un'indicazione di pericolo (codice H), un pittogramma e un'avvertenza.

Categorie della classe STOT RE

Tra le sostanze con classificazione armonizzata in questa classe sono presenti le seguenti categorie:

Pittogramma e avvertenza

Per questa classe, sull'etichetta CLP compaiono tipicamente i seguenti pittogrammi, con l'avvertenza Pericolo:

• GHS08 – Pericolo per la salute (CMR, sensibilizzanti respiratori, aspirazione, STOT)
• GHS09 – Ambiente (pericoloso per l’ambiente acquatico)
• GHS06 – Teschio e tibie incrociate (tossicità acuta)

Sostanze classificate come tossicità specifica per organi bersaglio – esposizione ripetuta

Esempi di sostanze con questa classificazione armonizzata (Allegato VI). Apri la scheda per vedere tutti i codici di classe, le indicazioni H e i pittogrammi:

• ( R )-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1 H
• ( S )-2,3-dihydro-1 H -indole-2-carboxylic acid
• ( S )-methyl-2-chloropropionate
• ( Z )-1-benzo[ b ]thien-2-ylethanone oxime hydrochlo
• ((4-phenylbutyl)hydroxyphosphoryl)acetic acid
• (2-(1,3-dioxolan-2-yl)ethyl)triphenylphosphonium bro
• (4-(1-methylethyl)phenyl)-(4-methylphenyl)iodonium t
• (4-ammonio- m -tolyl)ethyl(2-hydroxyethyl)ammonium s
• (4-hydrazinophenyl)- N -methylmethanesulfonamide hyd
• 1,1,3,3-tetrabutyl-1,3-ditinoxydicaprylate
• 1,2-dibromo-3-chloropropane
• 1,3,5-trinitrobenzene
• 1,3,5-tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1 H
• 1,3,5-tris-[(2 S and 2 R )-2,3-epoxypropyl]-1,3,5-tr
• 1,3-bis(3-methyl-2,5-dioxo-1 H -pyrrolinylmethyl)ben
• 1,3-dichloro-4-fluorobenzene
• 1,6-bis(3,3-bis((1-methylpentylidenimino)propyl)urei
• 1-(1,4-benzodioxan-2-ylcarbonyl)piperazine hydrochlo
• 1-(2,3-dihydro-1,3,3,6-tetramethyl-1-(1-methylethyl)
• 1-bromo-3,5-difluorobenzene
• 1-bromopropane
• 1-chloro-4-nitrobenzene
• 1-vinyl-2-pyrrolidone
• 2 S -isopropyl-5 R -methyl-1 R -cyclohexyl 2,2-dihyd
• 2,2'-iminodiethanol
• 2,2-dibromo-2-nitroethanol
• 2,3,4-trifluoroaniline
• 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
• 2,3-dinitrophenol
• 2,3-dinitrotoluene
• 2,3-epoxypropyl methacrylate
• 2,4,6-trinitro- m -xylene
• 2,4,6-trinitrotoluene
• 2,4-diamino-5-methoxymethylpyrimidine
• 2,4-dinitroaniline
• 2,4-dinitrophenol
• 2,4-dinitrotoluene
• 2,5-dinitrotoluene
• 2,6-diamino-3,5-diethyltoluene
• 2,6-dinitrotoluene
• 2,7,11-trimethyl-13-(2,6,6-trimethylcyclohex-1-en-1-
• 2- n -hexadecylhydroquinone
• 2-((4-(ethyl-(2-hydroxyethyl)amino)-2-methylphenyl)a
• 2-(2-(2-hydroxyethoxy)ethyl)-2-aza-bicyclo[2.2.1]hep
• 2-(3-(prop-1-en-2-yl)phenyl)prop-2-yl isocyanate
• 2-(3-chloropropyl)-2,5,5-trimethyl-1,3-dioxane
• 2-(4- tert -butylphenyl)ethanol
• 2-(4-(3-(4-chlorophenyl)-2-pyra zolin-1-yl)phenylsul
• 2-(4-(4-cyano-3-methylisothiazol-5-ylazo)- N -ethyl-
• 2-(7-ethyl-1 H -indol-3-yl)ethanol
• 2-(decylthio)ethylammonium chloride
• 2-(isocyanatosulfonylmethyl)benzoic acid methyl este
• 2-bromo-1-(2-furyl)-2-nitroethylene
• 2-bromo-2-nitropropanol
• 2-bromopropane
• 2-butyl-2-ethyl-1,5-diaminopentane
• 2-chloromethyl-3,4-dimethoxypyridinium chloride
• 2-ethoxyaniline
• 2-methoxyethylmercury chloride
• 2-methyl-2-azabicyclo[2.2.1]heptane
• 2-naphthylamino-6-sulfomethylamide
• 2-nitro- p -anisidine
• 2-nitro-2-phenyl-1,3-propanediol
• 3'-(3-acetyl-4-hydroxyphenyl)-1,1-diethylurea
• 3'-trifluoromethylisobutyranilide
• 3,4-dinitrotoluene
• 3,5-dinitrotoluene
• 3-acetyl-1-phenyl-pyrrolidine-2,4-dione
• 3-azidosulfonylbenzoic acid
• 3-chloropropene
• 3-cyano-3,5,5-trimethylcyclohexanone
• 3-dodecyl-(1-(1,2,2,6,6-pentamethyl-4-piperidin)-yl)
• 3-tridecyloxy-propyl-ammonium 9-octadecenoate
• 4,4'-diamino-2-methylazobenzene
• 4,4'-diaminodiphenylmethane
• 4,4'-ethylidenediphenyl dicyanate
• 4,4'-methylenebis( N , N '-dimethylcyclohexanamine
• 4,4'-methylenebis(2-isopropyl-6-methylaniline)
• 4,4'-methylenediphenyl diisocyanate
• 4-(1-oxo-2-propenyl)-morpholine
• 4-(2-chloro-4-trifluoromethyl)phenoxy-2-fluoroanilin
• 4-(2-cyano-3-phenylamino acryloyloxymethyl)-cyclohex
• 4-(3,4-dichlorophenylazo)-2,6-di- sec -butyl-phenol
• 4-(4-nitrophenylazo)-2,6-di- sec -butyl-phenol
• 4-(4-tolyloxy)biphenyl
• 4-[3-(diethoxymethylsilylpropoxy)-2,2,6,6-tetramethy
• 4-dimethylaminobenzenediazonium 3-carboxy-4-hydroxyb
• 4-methoxy- N ,6-dimethyl-1,3,5- triazin-2-ylamine
• 4-methyl- m -phenylenediamine
• 4-nitrophenol
• 4-nitrotoluene
• 5,5-dimethyl-perhydro-pyrimidin-2-one α-(4-trifluoro
• 5- tert -butyl-3-isoxazolylamine hydrochloride
• 5-acetyl-3-amino-10,11-dihydro-5 H -dibenz[ b, f ]az
• acetochlor (ISO)
• acrylamide
• aldrin (ISO)
• amitraz (ISO)
• amitrole (ISO)
• ammonium dichromate
• ammonium salt of DNOC
• arsine
• asbestos
• atrazine (ISO)
• azafenidin (ISO)
• azobenzene
• benzene
• beryllium
• beryllium compounds with the exception of aluminium
• beryllium oxide
• bis( N -(7-hydroxy-8-methyl-5-phenylphenazin-3-ylide
• bis(2,4,6-trinitrophenyl)amine
• bis(4-hydroxy-N-methylanilinium) sulphate
• bis(η5-cyclopentadienyl)-bis(2,6-difluoro-3-[pyrrol-
• brodifacoum (ISO)
• bromobenzylbromotoluene, reaction mass of isomers
• bromomethane
• but-2-yne-1,4-diol
• butanone oxime
• cadmium (non-pyrophoric)
• cadmium (pyrophoric)
• cadmium chloride
• cadmium cyanide
• cadmium diformate
• cadmium fluoride
• cadmium iodide
• cadmium sulphate
• cadmium sulphide
• cadmiumhexafluorosilicate(2-)
• carbon disulphide
• carbon monoxide
• carbon tetrachloride
• chloroacetyl chloride
• chloroanilines (with exception of those specified el
• chlorodinitrobenzene
• chloroform
• chloromethane
• chloronitroanilines with the exception of those spec
• chlorophacinone (ISO)
• chloroprene (stabilised)
• chromium (VI) trioxide
• cis -1-(3-chloropropyl)-2,6-dimethyl-piperidin hydro
• colecalciferol
• coumachlor (ISO)
• coumafuryl (ISO)
• coumatetralyl (ISO)
• crotonaldehyde
• cyanamide
• cyclopentyl chloroformate
• cymoxanil (ISO)
• cypermethrin (ISO)
• cyproconazole (ISO)
• DDT (ISO)
• di(tetramethylammonium)(29H,31H-phthalocyanin-N29,N3
• dibenzylphenylsulfonium hexafluoroantimonate
• dibutyltin hydrogen borate
• dichloroacetylene
• dicoumarol
• dieldrin (ISO)
• difenacoum (ISO)
• digitoxin
• dimercury dicyanide oxide
• dimethylmercury
• dimethylnitrosoamine
• dinickel trioxide
• dinitrobenzene
• dinitrophenol (reaction mass of isomers)
• dinocap (ISO)
• diphacinone (ISO)
• diphenyl ether, pentabromo derivative pentabromodiph
• diphenylamine
• dipicrylamine, ammonium salt
• diquat dibromide
• disulfiram
• dithallium sulphate
• diuron (ISO)
• divanadium pentaoxide
• dodemorph (ISO)
• ergocalciferol (ISO)
• etacelasil (ISO)
• ethyl 2-(1-cyanocyclohexyl)acetate
• ethyl 2-(isocyanatosulfonyl)benzoate
• ethylbenzene
• ethylene dinitrate
• ethylene oxide
• famoxadone (ISO)
• fenthion (ISO)
• fentin acetate (ISO)
• fentin hydroxide (ISO)
• flocoumafen (ISO)
• flufenacet (ISO)
• fluquinconazole (ISO)
• fuberidazole (ISO)
• furan
• furathiocarb (ISO)
• glycerol trinitrate
• glycerol trinitrate
• heptachlor (ISO)
• heptachlor epoxide
• hexachlorobenzene
• hexan-2-one
• hydroxylamine … % [> 55 % in aqueous solution]
• hydroxylammonium chloride
• hydroxyphosphonoacetic acid
• Inorganic compounds of mercury with the exception of
• ioxynil (ISO) 4-hydroxy-3,5-diiodobenzonitrile
• isazofos (ISO)
• isoproturon (ISO)
• lead 2,4,6-trinitro- m -phenylene dioxide
• lead 2,4,6-trinitro- m -phenylene dioxide
• lead acetate, basic
• lead alkyls
• lead chromate
• lead chromate molybdate sulfate red
• lead compounds with the exception of those specified
• lead di(acetate)
• lead diazide
• lead diazide
• lead hexafluorosilicate
• lead hydrogen arsenate
• lead sulfochromate yellow
• lead(II) methanesulphonate
• lindane (ISO)
• linuron (ISO)
• lithium bis(trifluoromethylsulfonyl)imide
• m -toluidine
• maleic anhydride
• mancozeb (ISO)
• manganese sulphate
• mercury
• mercury dichloride
• mercury difulminate
• mercury difulminate
• mesotrione (ISO)
• methyl 3-isocyanatosulfonyl-2-thiophene-carboxylate
• methyl-phenylene diamine
• metribuzin (ISO)
• molinate (ISO)
• monolinuron (ISO)
• N , N -diethylaniline
• N , N -dimethyl-m-toluidine
• N -ethylaniline
• n -hexane
• N -methyl- N -2,4,6-tetranitroaniline
• N -methyl- o -toluidine
• N -methylaniline
• N, N -diethyl- N',N' -dimethylpropan-1,3-diyl-diamin
• N, N -dimethyl-2-(3-(4-chloro phenyl)-4,5-dihydropyr
• N, N -hydrazinodiacetic acid
• naphtha (petroleum), hydrodesulphurized heavy
• nickel
• nickel (II) sulfide
• nickel carbonate
• nickel dihydroxide
• nickel dioxide
• nickel monoxide
• nickel sulfate
• niline
• nitrobenzene
• nitrotoluidines, with the exception of those specifi
• O -ethylhydroxylamine
• O, O' -(ethenylmethylsilylene)di[(4-methylpentan-2-o
• o-nitroaniline
• organic compounds of mercury with the exception of t
• ouabain
• oxadiargyl (ISO)
• oxasulfuron (ISO)
• oxydiethylene dinitrate
• oxydiethylene dinitrate
• p -anisidine
• paraquat dichloride
• parathion (ISO)
• parathion — methyl (ISO)
• pentachloroethane
• phenol
• phenylhydrazine
• phenylmercury acetate
• phenylmercury nitrate
• phosphorus pentachloride
• phosphorus trichloride
• phosphoryl trichloride
• pindone (ISO)
• pirimiphos-methyl (ISO)
• polychlorobiphenyls
• potassium dichromate
• potassium N -(4-fluorophenyl)glycinate
• quinomethionate
• quizalofop-P-tefuryl (ISO)
• reaction mass of 7-[4-(3-diethylaminopropylamino)-6-
• reaction mass of: 2-[ N -ethyl-4-[(5,6-dichlorobenzo
• reaction mass of: 5-( N -methylperfluorooctylsulfona
• reaction mass of: 5-[(4-[(7-amino-1-hydroxy-3-sulfo-
• reaction mass of: bis(1 S ,2 S ,4 S )-(1-benzyl-4- t
• reaction mass of: butan-2-one oxime
• reaction mass of: dodecyl N -(2,2,6,6-tetramethylpip
• reaction mass of: N -(3-dimethylamino-4-methyl-pheny
• reaction mass of: N -[3-hydroxy-2-(2-methylacryloyla
• reaction mass of:[2-(anthraquinon-1-ylamino)-6-[(5-b
• salts of aniline
• salts of ioxynil with the exception of those specifi
• selenium
• selenium compounds with the exception of cadmium sul
• sodium 4-(2,4,4-trimethylpentylcarbonyloxy)benzenesu
• sodium chromate
• sodium dichromate
• sodium salt of DNOC
• spiroxamine (ISO)
• stoddard solvent
• strophantin-K
• styrene
• sulphuryl difluoride
• tert -butyl (triphenylphosphoranylidene) acetate
• tetradecylammonium bis(1-(5-chloro-2-oxidophenylazo)
• tetramethylammonium hydrogen phthalate
• thallium
• thallium compounds, with the exception of those spec
• thallium thiocyanate
• thiram (ISO)
• toluene
• tolylfluanid (ISO)
• tri-allate (ISO)
• tributyltetradecylphosphonium tetrafluoroborate
• tributyltin compounds, with the exception of those s
• trilead bis(orthophosphate)
• trinickel disulfide
• trioctylstannane
• trisodium hexafluoroaluminate [1] trisodium hexafluo
• uranium
• uranium compounds with the exception of those specif
• UVCB condensation product of: tetrakis-hydroxymethyl
• vanadium(IV) oxide hydrogen phosphate hemihydrate, l
• warfarin (ISO)
• xylidines with the exception of those specified else
• ziram (ISO)
• α, α, α,4-tetrachlorotoluene
• α, α-dimethylbenzyl hydroperoxide
• α-chlorotoluene
• α-cypermethrin (ISO)

Obblighi pratici

Se un prodotto contiene una sostanza di questa classe sopra le soglie pertinenti, la classificazione si riflette su etichetta CLP (pittogramma, avvertenza, indicazioni H, consigli P), scheda dati di sicurezza (sezioni 2 e 15), imballaggio ed eventuale notifica al centro antiveleni. Per le miscele il contributo dipende dalla concentrazione e da eventuali limiti specifici o fattori M.

Altre classi di pericolo salute

Il CLP raggruppa le classi in pericoli fisici, per la salute e per l'ambiente. Altre classi del gruppo «salute»:

• Tossicità acuta (Acute Tox.)
• Corrosione della pelle (Skin Corr.)
• Irritazione cutanea (Skin Irrit.)
• Gravi lesioni oculari (Eye Dam.)
• Irritazione oculare (Eye Irrit.)
• Sensibilizzazione respiratoria (Resp. Sens.)
• Sensibilizzazione cutanea (Skin Sens.)
• Mutagenicità sulle cellule germinali (Muta.)
• Cancerogenicità (Carc.)
• Tossicità per la riproduzione (Repr.)
• Effetti sull’allattamento o attraverso l’allattamento (Lact.)
• Tossicità specifica per organi bersaglio – esposizione singola (STOT SE)
• Pericolo in caso di aspirazione (Asp. Tox.)

Fonti

Classe e categorie secondo l'Allegato I e l'Allegato VI del Regolamento (CE) n. 1272/2008 (CLP). Gli elenchi di sostanze derivano dalla Tabella 3.1 dell'Allegato VI; verifica sempre la versione consolidata vigente e l'inventario C&L dell'ECHA.

Domande frequenti

Come faccio a sapere se una sostanza rientra in questa classe?

Si controlla la sua classificazione: nelle schede per sostanza trovi i codici di classe e categoria di pericolo tratti dall'Allegato VI del CLP, oppure si applica l'autoclassificazione sulla base dei dati disponibili.

Questa classe richiede un pittogramma in etichetta?

Sì, quando previsto dalla categoria: in etichetta CLP vanno riportati pittogramma, avvertenza, indicazioni di pericolo (H) e consigli di prudenza (P) coerenti con la classificazione.

Dove ritrovo l'elenco completo delle sostanze tossicità specifica per organi bersaglio – esposizione ripetuta?

In questa pagina trovi gli esempi collegati alle schede; l'elenco completo è nell'archivio delle schede CLP per sostanza.

La classificazione può cambiare nel tempo?

Sì: gli ATP (adeguamenti al progresso tecnico) aggiornano l'Allegato VI. Verifica sempre la versione consolidata vigente e l'inventario C&L dell'ECHA.